Journal: PLoS ONE
Article Title: AdHu5Ag85A Respiratory Mucosal Boost Immunization Enhances Protection against Pulmonary Tuberculosis in BCG-Primed Non-Human Primates
doi: 10.1371/journal.pone.0135009
Figure Lengend Snippet: Animals were infected with 25 colony-forming units of M . tb Erdman strain. Group coloring in the survival graph is maintained throughout the article for comparability of data. One animal in BCG/Ad(im) group died accidently and is excluded from data analysis ( A ). Overall log-rank test for trend yielded p = 0.0247, but no statistical differences between groups. Colony-forming units (CFU) of mycobacteria was measured per gram of randomly selected tissue from different lung lobs or spleen at necropsy. CFU per right lung ( B ), left lung ( C ) and spleen ( D ) were presented in logarithmic numbers. P-values above lines indicate comparison between groups. Mann-Whitney rank test is used to compare differences relative to naïve group.
Article Snippet: A stock of the M . tb Erdman strain obtained from the Food and Drug Administration (Bethesda, MD, United States) through Aeras Global TB Vaccine Foundation was used for infection.
Techniques: Infection, Comparison, MANN-WHITNEY